Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545584 | 0.91 | MDM2 (0.45) | MDM2MAP2K4ELANENR1H2MEN1 | |
| SCHEMBL8544978 | 0.90 | MDM2 (0.42) | MDM2ELANENR1H2MAPTALDH1A1 | |
| SCHEMBL8540094 | 0.85 | MDM2 (0.44) | MDM2ELANENR1H2MAPTALDH1A1 | |
| SCHEMBL8545030 | 0.85 | ELANE (0.46) | MDM2ELANEMAPTALDH1A1MEN1 | |
| SCHEMBL8545397 | 0.81 | MDM2 (0.44) | MDM2MAP2K4ELANENR1H2MEN1 | |
| SCHEMBL8540741 | 0.81 | MDM2 (0.38) | MDM2MAPTALDH1A1CYP1A2MEN1 | |
| SCHEMBL8545442 | 0.81 | MDM2 (0.46) | MDM2ELANENR1H2ALDH1A1MEN1 | |
| SCHEMBL8545340 | 0.81 | MDM2 (0.45) | MDM2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8538967 | 0.79 | MDM2 (0.44) | MDM2ELANENR1H2MAPTALDH1A1 | |
| SCHEMBL8918752 | 0.77 | MDM2 (0.51) | MDM2MAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |