Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543997 | 0.89 | MDM2 (0.43) | MDM2ALOX15CRHBPCRHR2MAPT | |
| SCHEMBL8541107 | 0.82 | MDM2 (0.47) | MDM2CRHBPCRHR2MAPTALDH1A1 | |
| SCHEMBL8545340 | 0.81 | MDM2 (0.45) | MDM2MAPK8MAPK9MAPTALDH1A1 | |
| SCHEMBL8540094 | 0.79 | MDM2 (0.44) | MDM2CRHBPCRHR2MAPTTHRB | |
| SCHEMBL8544978 | 0.78 | MDM2 (0.42) | MDM2MAPTALDH1A1 | |
| SCHEMBL8545400 | 0.77 | MDM2 (0.41) | MDM2MAPTALDH1A1CYP1A2 | |
| SCHEMBL8538967 | 0.77 | MDM2 (0.44) | MDM2CRHBPCRHR2MAPTALDH1A1 | |
| SCHEMBL8547269 | 0.77 | MDM2 (0.40) | MDM2ALOX15CRHBPCRHR2MAPT | |
| SCHEMBL8545030 | 0.76 | ELANE (0.46) | MDM2MAPTTHRBALDH1A1 | |
| SCHEMBL8543993 | 0.75 | MDM2 (0.45) | MDM2CRHBPCRHR2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |