Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | PARP11 | Q9NR21 | 8/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989227 | 0.80 | MAOB (0.56) | ADRA2AADRA2BADRA2CMEN1LMNA | |
| SCHEMBL30527041 | 0.79 | PARP11 (0.55) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL21040262 | 0.79 | PARP11 (0.55) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL1036450 | 0.79 | KCNA5 (0.53) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL19574541 | 0.79 | PARP11 (0.55) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL25597402 | 0.78 | PARP11 (0.50) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL12502617 | 0.78 | PARP11 (0.50) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL1239440 | 0.78 | PARP11 (0.50) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL21845116 | 0.77 | PARP11 (0.47) | PARP11PARP10GABRG2GABRB3GABRA5 | |
| SCHEMBL3959550 | 0.77 | MAOB (0.60) | ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526402-B1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA GEIGY AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| US-5350761-A | Lipoxygenase inhibitors as antiinflammatory agents and antiallergens | CIBA-GEIGY CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| US-5334600-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| US-5260316-A | Lipoxygenase inhibitor | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0526402-A1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |