Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27367557 | 0.93 | AGTR1 (0.39) | AGTR1 | |
| SCHEMBL9535254 | 0.92 | AGTR1 (0.38) | AGTR1 | |
| SCHEMBL8545586 | 0.88 | AGTR1 (0.38) | AGTR1 | |
| SCHEMBL9311227 | 0.87 | AGTR1 (0.35) | AGTR1 | |
| SCHEMBL8544342 | 0.87 | AGTR1 (0.35) | AGTR1 | |
| SCHEMBL9311241 | 0.84 | AGTR1 (0.35) | AGTR1 | |
| SCHEMBL9310941 | 0.81 | AGTR1 (0.51) | AGTR1 | |
| SCHEMBL9859304 | 0.81 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL9481748 | 0.81 | AGTR1 (0.45) | AGTR1 | |
| SCHEMBL8544153 | 0.81 | AGTR1 (0.42) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | disclosed |
| US-5498722-A | HYPOTENSIVES | GLAXO GROUP (GB) | 1996-03-12 | — | — | US | disclosed |
| EP-0520724-B1 | Angiotensin II antagonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| US-5281613-A | Heterocyclic ring substituted benzofuran, benzothiofuran, or indole derivative | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-25 | — | — | US | disclosed |
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5252593-A | Hypotensive agents, cognition activators | GLAXO GROUP LIMITED (GB) | 1993-10-12 | — | — | US | disclosed |
| EP-0559724-A1 | BENZOFURAN AND BENZTHIOPHENE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1993-09-15 | — | — | EP | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514217-A1 | Antihypertensive benzofuran derivatives carrying 4-pyrazolylmethyl substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514192-A1 | Antihypertensive benzofuran derivatives, substituted by varied N-pyrimidinyl- or N-imidazolyl-methyl groups | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| EP-0514198-A1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016552-A1 | 1-IMIDAZOLGEMETHYL BENZOFURAN DERIVATIVES AS INHIBITORS OF ANGIOTENSIN II ACTIVITY | GLAXO GROUP LIMITED (GB) | 1992-10-01 | — | — | WO | disclosed |
| EP-0505954-A1 | N-Imidazolylmethyl benzofuran derivatives as inhibitors of angiotensin II activity | GLAXO GROUP LIMITED (GB) | 1992-09-30 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |
| WO-1992009600-A1 | BENZOFURAN AND BENZTHIOPHENE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-06-11 | — | — | WO | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |