Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548053 | 0.90 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8546898 | 0.90 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8544742 | 0.87 | MAPT (0.53) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8550665 | 0.84 | MAPT (0.49) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8541121 | 0.84 | KDM4E (0.53) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8544221 | 0.82 | ALDH1A1 (0.82) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8543140 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8547302 | 0.82 | MAPT (0.51) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8549098 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL8544752 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557075-B1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY CO ELI (GB) | 1998-06-24 | — | — | EP | disclosed |
| US-5663375-A | CELL PROLIFERATION | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5622987-A | PREVENT MIGRATION OR PROLIFERATION OF SMOOTH MUSCLE CELLS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5378699-A | Treatment of immune diseases, cell proliferation, restenosis and smooth muscle cells | LILLY INDUSTRIES LIMITED (GB) | 1995-01-03 | — | — | US | disclosed |
| US-5378717-A | Therapy for diabetic complications | ELI LILLY AND COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0557075-A1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY INDUSTRIES LIMITED (GB) | 1993-08-25 | — | — | EP | disclosed |