Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYB | P10242 | 10/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545703 | 1.00 | MYB (0.52) | MYBSMN1; SMN2KMT2ACYP2C19LMNA | |
| SCHEMBL8539142 | 0.84 | MYB (0.61) | MYBSMN1; SMN2KMT2ALMNACYP1A2 | |
| SCHEMBL8539335 | 0.81 | MYB (0.75) | MYBKMT2ALMNACYP1A2MEN1 | |
| SCHEMBL8538222 | 0.78 | MYB (0.61) | MYBSMN1; SMN2KMT2ALMNACYP1A2 | |
| SCHEMBL8540789 | 0.75 | MYB (0.55) | MYBSMN1; SMN2KMT2ALMNACYP1A2 | |
| SCHEMBL9343227 | 0.75 | MYB (0.70) | MYBSMN1; SMN2KMT2ACYP2C19LMNA | |
| SCHEMBL8542563 | 0.74 | MYB (0.57) | MYBSMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL8542568 | 0.74 | MYB (0.57) | MYBSMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL8540958 | 0.70 | MYB (0.75) | MYBKMT2ALMNACYP1A2MEN1 | |
| SCHEMBL10275379 | 0.70 | MYB (0.74) | MYBKMT2ALMNACYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |