SCHEMBL854575

SCHEMBL854575

O=C1OCc2c1ccc(Cl)c2Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNJ1 P48048 9/20 0.46
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
KCNH2 Q12809 6/20 0.40
MAPT P10636 2/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.38
ACHE P22303 1/20 0.37
SSTR1 P30872 1/20 0.37
SLC6A4 P31645 1/20 0.37
CES1 P23141 1/20 0.36
ALOX5 P09917 1/20 0.36
TYMS P04818 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
HPGD P15428 1/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855133 0.81 KCNJ1 (0.44) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL2733555 0.81 KCNJ1 (0.44) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL30365884 0.81 KCNJ1 (0.44) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL286755 0.81 KCNJ1 (0.44) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL29568305 0.78 KCNJ1 (0.46) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL22718951 0.78 KCNJ1 (0.66) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL29567640 0.78 KCNJ1 (0.66) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL22718931 0.78 KCNJ1 (0.46) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL87504 0.78 MAOB (0.47) KCNJ1MAOAMAOBKCNH2MAPT
SCHEMBL29504833 0.78 MAOB (0.47) KCNJ1MAOAMAOBKCNH2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105849094-B The manufacture method of halogen-substituted phthalein 住友化学株式会社 2018-04-10 CN disclosed
CN-105849094-A Method for producing halogen-substituted phthalide 住友化学株式会社 2016-08-10 CN disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
US-20120142946-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
EP-2433933-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE Sumitomo Chemical Company, Limited (JP) 2012-03-28 EP disclosed