Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6167839 | 0.98 | HPGD (0.40) | HPGDHSD11B1DPP4ALDH1A1TSHR | |
| SCHEMBL6138922 | 0.82 | DPP4 (0.55) | DPP4PREPFAP | |
| SCHEMBL10379372 | 0.76 | DPP4 (0.53) | HPGDDPP4HDAC2FAP | |
| SCHEMBL12408422 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL5480201 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL14605825 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL497280 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL4550519 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL22418410 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 | |
| SCHEMBL8452004 | 0.76 | CYP2D6 (0.52) | TSHRPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618193-B1 | Nitrogen containing bicyclic derivatives as prolyl-endopeptidase inhibitors | ADIR (FR) | 1998-10-21 | — | — | EP | disclosed |
| US-5506237-A | PROLYL-ENDOPEPTIDASE INHIBITOR; USEFUL FOR TREATING OR PREVENTING MEMORY LOSS DUE TO AGING, ANXIETY AND DEPRESSION | ADIR ET COMPAGNIE (FR) | 1996-04-09 | — | — | US | disclosed |
| EP-0618193-A1 | Nitrogen containing bicyclic derivatives as prolyl-endopeptidase inhibitors | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |