SCHEMBL8546043

SCHEMBL8546043

C=CC=Cc1ccc(SC)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 12/20 0.52
CYP1B1 Q16678 12/20 0.52
CYP1A2 P05177 11/20 0.52
ALDH1A1 P00352 3/20 0.50
FBP1 P09467 1/20 0.48
MEN1 O00255 3/20 0.42
RAB9A P51151 3/20 0.42
KMT2A Q03164 3/20 0.42
LMNA P02545 2/20 0.42
MAPT P10636 2/20 0.42
GAA P10253 1/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
NPC1 O15118 2/20 0.41
NFKB1 P19838 2/20 0.41
NFKB2 Q00653 2/20 0.41
RELA Q04206 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8546041 1.00 CYP1A1 (0.52) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL2622608 0.86 CYP1A1 (0.59) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL7567897 0.81 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL13790243 0.81 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL8367958 0.81 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL13790333 0.81 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL27960203 0.78 ALDH1A1 (0.61) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL2091166 0.77 CYP1A1 (0.55) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL2091163 0.77 CYP1A1 (0.55) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1
SCHEMBL2622629 0.77 CYP1A2 (0.53) CYP1A1CYP1B1CYP1A2ALDH1A1FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0690842-B1 4-ARYLISOINDOLE ANALGESICS ORTHO PHARMA CORP (US) 1998-12-16 EP disclosed
US-5508424-A REDUCED SIDE EFFECTS ORTHO PHARMACEUTICAL CORPORATION (US) 1996-04-16 US disclosed
EP-0690842-A1 4-ARYLISOINDOLE ANALGESICS ORTHO PHARMACEUTICAL CORPORATION (US) 1996-01-10 EP disclosed
WO-1994022823-A1 4-ARYLISOINDOLE ANALGESICS ORTHO PHARMACEUTICAL CORPORATION (US) 1994-10-13 WO disclosed