Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 14/20 | 0.47 |
| ▸ | RXRB | P28702 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 3/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | C5 | P01031 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558227 | 0.84 | RXRA (0.58) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8546148 | 0.82 | RXRA (0.53) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8561179 | 0.82 | NR4A2 (0.51) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8556331 | 0.80 | KDM4E (0.56) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8557451 | 0.80 | RXRA (0.67) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8550567 | 0.80 | NR4A2 (0.51) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8560798 | 0.80 | NR4A2 (0.51) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8546881 | 0.79 | NR4A2 (0.52) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8560614 | 0.79 | RXRA (0.52) | RXRANR4A2RXRBKDM4EHPGD | |
| SCHEMBL8551829 | 0.79 | RXRA (0.68) | RXRANR4A2RXRBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |