Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16742125 | 0.90 | LMNA (0.52) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL25233675 | 0.89 | CYP3A4 (0.46) | KDM4EMEN1KMT2ATSHRABCB1 | |
| SCHEMBL5152746 | 0.85 | HSD17B2 (0.51) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL8547102 | 0.85 | KDM4E (0.52) | KDM4EABCB1PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL14211106 | 0.84 | KDM4E (0.50) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL25695892 | 0.83 | KDM4E (0.41) | KDM4EMEN1KMT2ATSHRABCB1 | |
| SCHEMBL12126791 | 0.82 | HSD17B2 (0.55) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL6580057 | 0.82 | HSD17B2 (0.67) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL20391513 | 0.81 | CA12 (0.50) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL27797045 | 0.80 | TSHR (0.66) | KDM4ECA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0584085-B1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5554606-A | THIENAMYCIN DERIVATIVES; PSEUDOMONAS | ZENECA LIMITED (GB) | 1996-09-10 | — | — | US | disclosed |
| EP-0584085-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992017479-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |