Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.52 |
| ▸ | EDNRA | P25101 | 5/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 3/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550269 | 0.91 | EDNRB (0.60) | EDNRBEDNRAPLA2G2AMEN1MAPT | |
| SCHEMBL8547872 | 0.90 | EDNRB (0.48) | EDNRBEDNRAPLA2G2AQPCTQPCTL | |
| SCHEMBL8549602 | 0.88 | EDNRB (0.46) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8546347 | 0.88 | EDNRB (0.66) | EDNRBEDNRA | |
| SCHEMBL8552478 | 0.88 | EDNRB (0.48) | EDNRBEDNRAPLA2G2AKDM4E | |
| SCHEMBL8546737 | 0.87 | EDNRB (0.49) | EDNRBEDNRAMEN1MAPTKMT2A | |
| SCHEMBL8548416 | 0.87 | EDNRB (0.50) | EDNRBEDNRAPLA2G2AMEN1TP53 | |
| SCHEMBL8551602 | 0.86 | EDNRB (0.69) | EDNRBEDNRAPLA2G2AMEN1TP53 | |
| SCHEMBL8550751 | 0.85 | EDNRB (0.46) | EDNRBEDNRAPLA2G2AKDM4E | |
| SCHEMBL8547974 | 0.85 | EDNRB (0.59) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |