Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.48 |
| ▸ | EDNRA | P25101 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546234 | 0.91 | EDNRB (0.57) | EDNRBEDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8546349 | 0.90 | EDNRB (0.52) | EDNRBEDNRAKDM4EGAAQPCT | |
| SCHEMBL8549337 | 0.90 | EDNRB (0.47) | EDNRBEDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8548047 | 0.89 | EDNRB (0.43) | EDNRBEDNRASMN1; SMN2KDM4EHPGD | |
| SCHEMBL8547512 | 0.88 | EDNRB (0.46) | EDNRBEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL8552520 | 0.88 | EDNRB (0.46) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8551956 | 0.88 | EDNRB (0.64) | EDNRBEDNRASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL8547254 | 0.88 | EDNRB (0.46) | EDNRBEDNRASMN1; SMN2LMNAKDM4E | |
| SCHEMBL8547971 | 0.88 | EDNRB (0.48) | EDNRBEDNRALMNAKDM4EALDH1A1 | |
| SCHEMBL8548805 | 0.87 | EDNRB (0.45) | EDNRBEDNRASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |