Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548576 | 0.96 | HTR1A (0.57) | HTR1AMEN1KMT2AOPRM1HTR2A | |
| SCHEMBL8548570 | 0.96 | HTR1A (0.57) | HTR1AMEN1KMT2AOPRM1HTR2A | |
| SCHEMBL13085827 | 0.70 | HTR1A (0.72) | HTR1AMEN1KMT2AOPRM1DRD4 | |
| SCHEMBL13085826 | 0.70 | HTR1A (0.72) | HTR1AMEN1KMT2AOPRM1DRD4 | |
| SCHEMBL8593020 | 0.70 | HTR1A (0.42) | HTR1AHTR2ADRD2DRD3 | |
| SCHEMBL8593022 | 0.70 | HTR1A (0.42) | HTR1AHTR2ADRD2DRD3 | |
| SCHEMBL8548574 | 0.70 | HTR1A (0.51) | HTR1AMEN1KMT2AOPRM1HTR2A | |
| SCHEMBL27347000 | 0.70 | HTR1A (0.73) | HTR1AMEN1KMT2AHTR2ADRD3 | |
| SCHEMBL27351354 | 0.70 | HTR1A (0.73) | HTR1AMEN1KMT2AHTR2ADRD3 | |
| SCHEMBL8120514 | 0.70 | HTR1A (0.42) | HTR1AMEN1KMT2ADRD4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711291-B1 | N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1998-11-25 | — | — | EP | disclosed |
| EP-0711291-A1 | N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995002592-A1 | N-(PIPERIDINYL-1-ALKYL)-SUBSTITUTED CYCLOHEXANE CARBOXYLIC ACID AMIDES AS 5-HT1A RECEPTOR ANTAGONISTS | JOHN WYETH & BROTHER LTD. (GB) | 1995-01-26 | — | — | WO | disclosed |