Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 13/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 12/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547101 | 0.87 | CA9 (0.53) | CA9CA2CA12ABCC9ABCC8 | |
| SCHEMBL17097221 | 0.78 | CA9 (0.58) | CA9CA2CA12ABCC9ABCC8 | |
| SCHEMBL2616815 | 0.76 | CA9 (0.59) | CA9CA2CA12ABCC9ABCC8 | |
| SCHEMBL13534186 | 0.75 | CA9 (0.58) | CA9CA2CA12ABCC9ABCC8 | |
| SCHEMBL8731341 | 0.70 | ALDH1A1 (0.50) | KMT2A | |
| SCHEMBL30872997 | 0.70 | ACE2 (0.60) | CA9CA2CA12RAB9AACE2 | |
| SCHEMBL107126 | 0.70 | CA9 (1.00) | CA9CA2CA12 | |
| SCHEMBL30339085 | 0.70 | CA9 (1.00) | CA9CA2CA12 | |
| SCHEMBL20172048 | 0.68 | CA9 (0.62) | CA9CA2CA12ABCC9ABCC8 | |
| SCHEMBL22226932 | 0.68 | CA9 (0.58) | CA9CA2CA12ABCC9ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752990-B1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5665749-A | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0752990-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026346-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1995-10-05 | — | — | WO | disclosed |