Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TLR3 | O15455 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL8545876 | 0.93 | KIT (0.55) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL24276997 | 0.90 | KIT (0.57) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL24277000 | 0.89 | KIT (0.54) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL24277001 | 0.89 | KIT (0.57) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL24277005 | 0.88 | KIT (0.54) | KITBCHEKDM4EKMT2AMEN1 | |
| Dimethylamine SCHEMBL8548190 | 0.87 | KIT (0.46) | KITGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8547834 | 0.86 | KIT (0.56) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL9091811 | 0.84 | KIT (0.59) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL9091805 | 0.84 | KIT (0.53) | KITBCHEKDM4EKMT2AMEN1 | |
| SCHEMBL29445100 | 0.84 | KDM4E (0.58) | KITBCHEKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |