Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.33 |
| ▸ | ADAM33 | Q9BZ11 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547641 | 0.97 | MAPK1 (0.44) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8541384 | 0.94 | MAPK1 (0.40) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8543037 | 0.93 | MAPK1 (0.41) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8543952 | 0.93 | MAPK1 (0.40) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8544269 | 0.90 | MAPK1 (0.41) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8548567 | 0.90 | MAPK1 (0.43) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8588573 | 0.87 | MAPK1 (0.39) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8543148 | 0.87 | MAPK1 (0.39) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL7238479 | 0.85 | MAPK1 (0.40) | MAPK1L3MBTL1GRM2ADAM33CA2 | |
| SCHEMBL8544359 | 0.84 | MAPK1 (0.40) | MAPK1L3MBTL1MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |