Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.52 |
| ▸ | EDNRA | P25101 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548743 | 0.94 | EDNRB (0.52) | EDNRBEDNRALMNAKMT2ATDP1 | |
| SCHEMBL8550774 | 0.93 | EDNRB (0.43) | EDNRBEDNRALMNAKMT2ATDP1 | |
| SCHEMBL8553120 | 0.93 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8551968 | 0.92 | EDNRB (0.55) | EDNRBEDNRALMNAKMT2APLA2G2A | |
| SCHEMBL8552637 | 0.91 | EDNRB (0.44) | EDNRBEDNRALMNAKMT2APLA2G2A | |
| SCHEMBL8551113 | 0.91 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL8552857 | 0.88 | EDNRB (0.40) | EDNRBEDNRALMNAMAPTALDH1A1 | |
| SCHEMBL8552691 | 0.88 | EDNRB (0.43) | EDNRBEDNRALMNAKMT2AMAPT | |
| SCHEMBL8552533 | 0.87 | EDNRB (0.52) | EDNRBEDNRALMNAKMT2APLA2G2A | |
| SCHEMBL8549919 | 0.87 | EDNRB (0.43) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |