Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.55 |
| ▸ | EDNRA | P25101 | 4/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591727 | 0.94 | EDNRB (0.56) | EDNRBEDNRAMAPTPOLBLMNA | |
| SCHEMBL8547310 | 0.93 | EDNRB (0.47) | EDNRBEDNRAPOLBKMT2A | |
| SCHEMBL8548815 | 0.93 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8548173 | 0.92 | EDNRB (0.52) | EDNRBEDNRAPLA2G2AMAPTPOLB | |
| SCHEMBL8551374 | 0.91 | EDNRB (0.47) | EDNRBEDNRAPLA2G2AMAPTPOLB | |
| SCHEMBL8545781 | 0.91 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL8551966 | 0.90 | EDNRB (0.69) | EDNRBEDNRAPLA2G2AKMT2A | |
| SCHEMBL8624245 | 0.88 | EDNRB (0.43) | EDNRBEDNRAPOLBALDH1A1 | |
| SCHEMBL8551305 | 0.87 | EDNRB (0.47) | EDNRBEDNRAPOLBPPARGKMT2A | |
| SCHEMBL8553569 | 0.87 | EDNRB (0.54) | EDNRBEDNRAMAPTPOLBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |