Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543464 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8548343 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8545128 | 0.81 | MAPT (0.56) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8542814 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8547334 | 0.80 | MAPT (0.51) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8547775 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8547862 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8543558 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8545296 | 0.78 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTLMNAMAPK1 | |
| SCHEMBL8543522 | 0.77 | MAPT (0.54) | ALDH1A1KDM4EMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557075-B1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY CO ELI (GB) | 1998-06-24 | — | — | EP | disclosed |
| US-5663375-A | CELL PROLIFERATION | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5622987-A | PREVENT MIGRATION OR PROLIFERATION OF SMOOTH MUSCLE CELLS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5378699-A | Treatment of immune diseases, cell proliferation, restenosis and smooth muscle cells | LILLY INDUSTRIES LIMITED (GB) | 1995-01-03 | — | — | US | disclosed |
| US-5378717-A | Therapy for diabetic complications | ELI LILLY AND COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0557075-A1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY INDUSTRIES LIMITED (GB) | 1993-08-25 | — | — | EP | disclosed |