Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.57 |
| ▸ | EDNRA | P25101 | 3/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547093 | 0.94 | EDNRB (0.53) | EDNRBEDNRAPLA2G2AMAPTMEN1 | |
| SCHEMBL8550230 | 0.93 | EDNRB (0.66) | EDNRBEDNRAPLA2G2AMAPTMEN1 | |
| SCHEMBL8546992 | 0.92 | EDNRB (0.69) | EDNRBEDNRAPLA2G2AMAPTMEN1 | |
| SCHEMBL8553797 | 0.92 | EDNRB (0.55) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550887 | 0.91 | EDNRB (0.58) | EDNRBEDNRAMAPTMEN1NPC1 | |
| SCHEMBL8553159 | 0.89 | EDNRB (0.54) | EDNRBEDNRAPLA2G2AMAPTMEN1 | |
| SCHEMBL8547247 | 0.89 | EDNRB (0.65) | EDNRBEDNRA | |
| SCHEMBL8550269 | 0.88 | EDNRB (0.60) | EDNRBEDNRAPLA2G2AMAPTMEN1 | |
| SCHEMBL6660199 | 0.87 | EDNRB (0.69) | EDNRBEDNRAMAPTMEN1GAA | |
| SCHEMBL8548527 | 0.87 | EDNRB (0.73) | EDNRBEDNRAMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |