Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.55 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551432 | 0.94 | EDNRB (0.64) | EDNRBEDNRAPLA2G2AALOX5APPPARG | |
| SCHEMBL8620818 | 0.93 | EDNRB (0.46) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8551761 | 0.92 | EDNRB (0.49) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8548530 | 0.92 | EDNRB (0.57) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8551615 | 0.91 | EDNRB (0.45) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8617491 | 0.91 | EDNRB (0.45) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8551281 | 0.90 | EDNRB (0.49) | EDNRBEDNRADYRK1AALOX5APPPARD | |
| SCHEMBL8547217 | 0.90 | EDNRB (0.46) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8551027 | 0.90 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8546992 | 0.89 | EDNRB (0.69) | EDNRBEDNRAPLA2G2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |