Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | QDPR | P09417 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29688867 | 0.82 | KCNH2 (0.45) | HTR2CHTR6HTR1ASLC6A4NPC1 | |
| SCHEMBL29688968 | 0.82 | HTR2C (0.46) | HTR2CHTR6HTR1ADRD2SLC6A4 | |
| SCHEMBL4491304 | 0.82 | KCNH2 (0.45) | HTR2CHTR6HTR1ASLC6A4NPC1 | |
| SCHEMBL4503187 | 0.82 | HTR2C (0.46) | HTR2CHTR6HTR1ADRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8916365 | 0.81 | HTR2C (0.47) | HTR2CHTR6HTR1ADRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7694678 | 0.81 | MPO (0.46) | HTR2CHTR6HTR1ASLC6A4 | |
| SCHEMBL8548177 | 0.79 | HTR1D (0.56) | HTR1DHTR1BDRD2SLC6A4CHRNB2 | |
| SCHEMBL7967288 | 0.78 | PTPN1 (0.44) | HTR2CHTR6DRD2SLC6A4CHRNB2 | |
| SCHEMBL13584551 | 0.78 | SLC6A4 (0.55) | HTR2CHTR6HTR1AADRB2DRD2 | |
| SCHEMBL20809221 | 0.75 | HTR2C (0.49) | HTR2CHTR1AADRB2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |