Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 5/20 | 0.46 |
| ▸ | CES1 | P23141 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087822 | 0.83 | CES2 (0.50) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL8148223 | 0.83 | CES2 (0.50) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL15680018 | 0.82 | CES2 (0.63) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL5444935 | 0.82 | CES2 (0.63) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL642607 | 0.75 | SLC6A4 (0.47) | LMNAALDH1A1TSHR | |
| SCHEMBL10392118 | 0.74 | CES2 (0.54) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL6203952 | 0.74 | CES2 (0.54) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL6836825 | 0.74 | CES2 (0.74) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL11186384 | 0.74 | CES2 (0.53) | CES2CES1LMNAALDH1A1KDM4E | |
| SCHEMBL4020285 | 0.74 | CES2 (0.74) | CES2CES1LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |