Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 8/20 | 0.33 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.32 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.32 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.32 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.32 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730283 | 0.84 | DPP4 (0.40) | KCNH2 | |
| SCHEMBL14730235 | 0.82 | DPP4 (0.35) | KCNH2 | |
| SCHEMBL8592971 | 0.78 | ALOX5AP (0.35) | GPR119HDAC6AOC3CAMK1DKCNH2 | |
| SCHEMBL8592327 | 0.76 | ALOX5AP (0.37) | GPR119CAMK1DHRH3 | |
| SCHEMBL14730361 | 0.76 | GPR119 (0.35) | GPR119CYP2C19KCNH2GPR183 | |
| SCHEMBL14730230 | 0.76 | DPP4 (0.38) | KCNH2 | |
| Hydrochloric Acid SCHEMBL14723514 | 0.75 | GPR119 (0.49) | GPR119KCNH2GPR183HRH3 | |
| SCHEMBL14730173 | 0.74 | PDK2 (0.34) | — | |
| SCHEMBL14730185 | 0.74 | GPR119 (0.34) | GPR119KCNH2GPR183 | |
| SCHEMBL14730288 | 0.73 | DPP4 (0.41) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066077-A1 | 1,4 DI SUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |