Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.49 |
| ▸ | EDNRA | P25101 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548507 | 0.95 | EDNRB (0.54) | EDNRBEDNRAGAASMN1; SMN2GRK2 | |
| SCHEMBL8551949 | 0.91 | EDNRB (0.54) | EDNRBEDNRAGAAMAPK1MEN1 | |
| SCHEMBL8552763 | 0.90 | EDNRB (0.47) | EDNRBEDNRAGAAMAPK1MEN1 | |
| SCHEMBL8549390 | 0.89 | EDNRB (0.48) | EDNRBEDNRAGRK2 | |
| SCHEMBL8551760 | 0.88 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8547128 | 0.87 | EDNRB (0.49) | EDNRBEDNRALMNA | |
| SCHEMBL8552129 | 0.87 | EDNRB (0.63) | EDNRBEDNRAMAPTSMN1; SMN2LMNA | |
| SCHEMBL8550537 | 0.86 | EDNRB (0.53) | EDNRBEDNRAKMT2AP2RX3 | |
| SCHEMBL8549608 | 0.86 | EDNRB (0.54) | EDNRBEDNRAGAAMAPK1MEN1 | |
| SCHEMBL8549381 | 0.85 | EDNRB (0.43) | EDNRBEDNRAGAAMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |