Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 18/20 | 0.63 |
| ▸ | EDNRA | P25101 | 16/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547840 | 0.92 | EDNRB (0.68) | EDNRBEDNRA | |
| SCHEMBL8550420 | 0.89 | EDNRB (0.61) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8552935 | 0.89 | EDNRB (0.60) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8550537 | 0.89 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8552763 | 0.88 | EDNRB (0.47) | EDNRBEDNRAMAPT | |
| SCHEMBL8549019 | 0.87 | EDNRB (0.49) | EDNRBEDNRALMNAMAPTSMN1; SMN2 | |
| SCHEMBL8547997 | 0.84 | EDNRB (0.54) | EDNRBEDNRALMNAMAPTHPGD | |
| SCHEMBL8549381 | 0.84 | EDNRB (0.43) | EDNRBEDNRAMAPT | |
| SCHEMBL8552822 | 0.83 | EDNRB (0.58) | EDNRBEDNRALMNASMN1; SMN2 | |
| SCHEMBL8549630 | 0.83 | EDNRB (0.52) | EDNRBEDNRALMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |