Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544116 | 0.79 | SMN1; SMN2 (0.35) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL8550018 | 0.78 | SMN1; SMN2 (0.38) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL8551357 | 0.76 | SMN1; SMN2 (0.37) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL11274814 | 0.76 | PLA2G1B (0.38) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL11272569 | 0.76 | SMN1; SMN2 (0.46) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL8546196 | 0.73 | LMNA (0.48) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL10372186 | 0.71 | MEN1 (0.42) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL9233800 | 0.68 | TSHR (0.39) | MEN1KMT2ANPC1GALR3NR2F2 | |
| SCHEMBL21721150 | 0.68 | — | — | |
| SCHEMBL21721126 | 0.67 | AKT1 (0.31) | SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717734-B1 | PYRIDAZINONE DERIVATIVES OR THEIR SALTS, PROCESSES FOR THEIR PRODUCTION, AND ANTI-SHOCK AGENTS CONTAINING THEM | ISHIHARA SANGYO KAISHA (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5763439-A | POTENTIATION | ISHIHARA SANGYO KAISHA LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0717734-A1 | PYRIDAZINONE DERIVATIVES OR THEIR SALTS, PROCESSES FOR THEIR PRODUCTION, AND ANTI-SHOCK AGENTS CONTAINING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007264-A1 | PYRIDAZINONE DERIVATIVES OR THEIR SALTS, PROCESSES FOR THEIR PRODUCTION, AND ANTI-SHOCK AGENTS CONTAINING THEM | ISHIHARA SANGYO KAISHA LTD. (JP) | 1995-03-16 | — | — | WO | disclosed |