Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.59 |
| ▸ | HTR1B | P28222 | 12/20 | 0.59 |
| ▸ | HTR2A | P28223 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543307 | 0.87 | HTR1D (0.71) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8389415 | 0.86 | HTR1D (0.72) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL5432776 | 0.79 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1MAPT | |
| Oxalic Acid SCHEMBL6924129 | 0.75 | HTR1D (0.86) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL5426990 | 0.75 | HTR1D (0.66) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6928454 | 0.74 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8147188 | 0.73 | HTR1D (0.66) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7175126 | 0.73 | HTR1D (0.59) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7403529 | 0.72 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6487806 | 0.72 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736023-B1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT 1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-08 | — | — | EP | claimed |