Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.48 |
| ▸ | HTR1B | P28222 | 10/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548938 | 0.88 | HTR1D (0.63) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8550766 | 0.86 | HTR1D (0.50) | HTR1DHTR1BDRD2CHRM2KDM4E | |
| SCHEMBL8547499 | 0.85 | HTR1D (0.46) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8590783 | 0.85 | DRD2 (0.46) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL7480337 | 0.85 | HTR1D (0.69) | HTR1DHTR1BDRD2CHRM2HTR1F | |
| SCHEMBL7486890 | 0.84 | HTR1D (0.67) | HTR1DHTR1BDRD2CHRM2HTR1F | |
| SCHEMBL8552647 | 0.84 | DRD2 (0.46) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8548023 | 0.83 | DRD2 (0.50) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8546639 | 0.83 | SMN1; SMN2 (0.48) | HTR1DHTR1BDRD2CHRM2SLC6A4 | |
| SCHEMBL8549937 | 0.83 | DRD2 (0.46) | HTR1DHTR1BDRD2CHRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |