Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.63 |
| ▸ | EDNRA | P25101 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550230 | 0.92 | EDNRB (0.66) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8547652 | 0.88 | EDNRB (0.64) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL6660199 | 0.86 | EDNRB (0.69) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8550789 | 0.86 | EDNRB (0.73) | EDNRBEDNRAGAAPLA2G2AKDM4E | |
| SCHEMBL8546234 | 0.86 | EDNRB (0.57) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8549274 | 0.85 | EDNRB (0.55) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8550269 | 0.85 | EDNRB (0.60) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8553159 | 0.85 | EDNRB (0.54) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL8553017 | 0.85 | EDNRB (0.54) | EDNRBEDNRAMAPTKMT2AMEN1 | |
| SCHEMBL6661772 | 0.85 | EDNRB (0.79) | EDNRBEDNRAPLA2G2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |