Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.79 |
| ▸ | EDNRA | P25101 | 7/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592785 | 0.93 | EDNRB (0.69) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8546992 | 0.93 | EDNRB (0.69) | EDNRBEDNRAPLA2G2APTGS2PPARG | |
| SCHEMBL6660199 | 0.93 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL8551602 | 0.93 | EDNRB (0.69) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550230 | 0.92 | EDNRB (0.66) | EDNRBEDNRAPLA2G2APTGS2 | |
| SCHEMBL8549097 | 0.91 | EDNRB (0.67) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550347 | 0.91 | EDNRB (0.66) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550822 | 0.91 | EDNRB (0.66) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8550789 | 0.91 | EDNRB (0.73) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8548888 | 0.91 | EDNRB (0.65) | EDNRBEDNRAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441721-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GmbH (DE) | 2004-08-04 | — | — | EP | claimed |
| WO-2003039539-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | claimed |
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | claimed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | claimed |
| EP-1441721-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GmbH (DE) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039539-A2 | USE OF ENDOTHELIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF TUMOUR DISEASES | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | disclosed |
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |