Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546607 | 0.86 | L3MBTL1 (0.42) | BRD4LMNASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL8889357 | 0.86 | CYP3A4 (0.42) | BRD4 | |
| SCHEMBL16979656 | 0.81 | BRD4 (0.52) | BRD4BRDTLMNAALDH1A1TTR | |
| SCHEMBL8790188 | 0.78 | TNKS2 (0.47) | BRD4TNKS2LMNASMN1; SMN2 | |
| SCHEMBL8790761 | 0.77 | TTR (0.50) | BRD4ALDH1A1TTRCES1MAPK7 | |
| SCHEMBL8706414 | 0.77 | PARP1 (0.34) | BRD4BRDTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8791033 | 0.74 | BRD4 (0.41) | BRD4TNKS2LMNAALDH1A1POLB | |
| SCHEMBL8299587 | 0.71 | CYP3A4 (0.52) | BRD4SMN1; SMN2ALDH1A1CASP1 | |
| SCHEMBL8299917 | 0.71 | TTR (0.40) | BRD4LMNASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL8300510 | 0.70 | TTR (0.42) | BRD4BRDTLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837704-A | PREVENTION OR TREATMENT OF AIDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0745083-B1 | 2-HETEROARYL-5,11-DIHYDRO-6H-DIPYRIDO [3,2-b:2',3'-e][1,4]DIAZEPINES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION | BOEHRINGER INGELHEIM PHARMA (US) | 1998-05-20 | — | — | EP | disclosed |