Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500813 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1KMT2A | |
| SCHEMBL7505580 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1KMT2A | |
| SCHEMBL8550703 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1CA1CA2CA4 | |
| SCHEMBL213986 | 0.84 | PTGS2 (0.78) | PTGS2PTGS1KMT2ACA1CA2 | |
| SCHEMBL8551037 | 0.84 | PTGS2 (0.78) | PTGS2PTGS1KMT2ACA1CA2 | |
| SCHEMBL7505993 | 0.84 | PTGS2 (0.86) | PTGS2PTGS1KMT2ACA1CA2 | |
| SCHEMBL31194857 | 0.83 | MAPK13 (0.60) | PTGS2PTGS1KMT2A | |
| SCHEMBL6516453 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1KMT2A | |
| SCHEMBL7501172 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1KMT2ACA1CA2 | |
| SCHEMBL7624713 | 0.79 | PTGS2 (0.59) | PTGS2PTGS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | claimed |
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |