Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552577 | 1.00 | TP53 (0.53) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL8550101 | 1.00 | TP53 (0.53) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL8549398 | 0.90 | TP53 (0.55) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL8549406 | 0.90 | TP53 (0.55) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL6587391 | 0.86 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL6582335 | 0.86 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| Hydrochloric Acid SCHEMBL8550512 | 0.85 | KDM4E (0.55) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| Hydrochloric Acid SCHEMBL8550521 | 0.85 | KDM4E (0.55) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL6832811 | 0.79 | TP53 (0.51) | TP53SMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL6832809 | 0.79 | TP53 (0.51) | TP53SMN1; SMN2MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | disclosed |