Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 7/20 | 0.49 |
| ▸ | GLA | P06280 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549406 | 1.00 | TP53 (0.55) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8552577 | 0.90 | TP53 (0.53) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8550094 | 0.90 | TP53 (0.53) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8550101 | 0.90 | TP53 (0.53) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6583386 | 0.86 | KDM4E (0.64) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8550750 | 0.86 | KDM4E (0.64) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6583378 | 0.86 | KDM4E (0.64) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6832809 | 0.83 | TP53 (0.51) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6832811 | 0.83 | TP53 (0.51) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6587391 | 0.82 | SMN1; SMN2 (0.57) | TP53MAPTSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | disclosed |