Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8405338 | 0.89 | POLB (0.54) | POLBRAB9ANPC1SMN1; SMN2RECQL | |
| SCHEMBL590420 | 0.83 | POLB (0.62) | POLBRAB9ANPC1SMN1; SMN2RECQL | |
| SCHEMBL5582508 | 0.82 | POLB (0.58) | POLBRAB9ANPC1SMN1; SMN2RECQL | |
| SCHEMBL8407836 | 0.81 | POLB (0.54) | POLBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL14055465 | 0.81 | POLB (0.59) | POLBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL592715 | 0.80 | POLB (0.66) | POLBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL8867533 | 0.79 | POLB (0.64) | POLBRAB9ANPC1SMN1; SMN2RECQL | |
| SCHEMBL3968088 | 0.79 | POLB (0.64) | POLBRAB9ANPC1SMN1; SMN2RECQL | |
| SCHEMBL11441693 | 0.78 | CA1 (0.63) | POLBALDH1A1KMT2A | |
| SCHEMBL21054940 | 0.78 | POLB (0.62) | POLBRAB9ANPC1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828731-A1 | TRICYCLIC DIAZEPINES USEFUL AS GnRH RECEPTOR ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-03-18 | — | — | EP | disclosed |