Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.60 |
| ▸ | EDNRA | P25101 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549564 | 0.95 | EDNRB (0.53) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8552415 | 0.92 | EDNRB (0.65) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8547606 | 0.88 | EDNRB (0.56) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8552822 | 0.87 | EDNRB (0.58) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8552726 | 0.87 | EDNRB (0.46) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8552414 | 0.87 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8547813 | 0.86 | EDNRB (0.64) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8550789 | 0.86 | EDNRB (0.73) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8549940 | 0.86 | EDNRB (0.61) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8551956 | 0.86 | EDNRB (0.64) | EDNRBEDNRAKDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |