Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 13/20 | 0.65 |
| ▸ | EDNRA | P25101 | 10/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547606 | 0.94 | EDNRB (0.56) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8550307 | 0.92 | EDNRB (0.60) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8552414 | 0.90 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8553472 | 0.89 | EDNRB (0.81) | EDNRBEDNRA | |
| SCHEMBL8549564 | 0.87 | EDNRB (0.53) | EDNRBEDNRANPC1CLK1RAB9A | |
| SCHEMBL8592785 | 0.86 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL6661772 | 0.86 | EDNRB (0.79) | EDNRBEDNRAPPARG | |
| SCHEMBL8594151 | 0.85 | EDNRB (0.63) | EDNRBEDNRA | |
| SCHEMBL8551602 | 0.85 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL8550347 | 0.85 | EDNRB (0.66) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |