Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.65 |
| ▸ | HTR1A | P08908 | 6/20 | 0.65 |
| ▸ | DRD2 | P14416 | 5/20 | 0.65 |
| ▸ | HTR2A | P28223 | 5/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.65 |
| ▸ | HTR1B | P28222 | 9/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400675 | 0.89 | HTR1D (0.78) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL7401245 | 0.85 | HTR1D (0.73) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL8551188 | 0.82 | HTR1D (0.78) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL8553214 | 0.82 | HTR1D (0.79) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL7397421 | 0.81 | HTR1D (0.84) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL7403421 | 0.81 | HTR1D (0.81) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL8549393 | 0.81 | HTR1D (0.77) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL6811486 | 0.81 | HTR1D (0.72) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL5090634 | 0.80 | HTR1D (0.63) | HTR1DHTR1ADRD2HTR2ADRD4 | |
| SCHEMBL7403907 | 0.79 | HTR1D (0.65) | HTR1DHTR1ADRD2HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |