Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 16/20 | 0.77 |
| ▸ | DRD2 | P14416 | 6/20 | 0.77 |
| ▸ | HTR2A | P28223 | 6/20 | 0.77 |
| ▸ | HTR1A | P08908 | 6/20 | 0.77 |
| ▸ | DRD4 | P21917 | 3/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.67 |
| ▸ | HTR1B | P28222 | 7/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644454 | 0.91 | HTR1D (0.78) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL7401245 | 0.89 | HTR1D (0.73) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8550158 | 0.87 | HTR1D (1.00) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8550714 | 0.87 | HTR1D (1.00) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL7403625 | 0.87 | HTR1D (1.00) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8592601 | 0.86 | DRD2 (0.56) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL7400675 | 0.86 | HTR1D (0.78) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL7403421 | 0.84 | HTR1D (0.81) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL6811486 | 0.83 | HTR1D (0.72) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8553214 | 0.83 | HTR1D (0.79) | HTR1DDRD2HTR2AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| WO-1997002259-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-23 | — | — | WO | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002259-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-23 | — | — | WO | disclosed |