Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.49 |
| ▸ | EDNRA | P25101 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551764 | 0.94 | EDNRB (0.53) | EDNRBEDNRAPOLBKDM4E | |
| SCHEMBL8548034 | 0.93 | EDNRB (0.49) | EDNRBEDNRAMEN1GAAMAPT | |
| SCHEMBL8550573 | 0.90 | EDNRB (0.41) | EDNRBEDNRAPOLBMEN1GAA | |
| SCHEMBL8546565 | 0.90 | EDNRB (0.49) | EDNRBEDNRAMEN1GAAMAPT | |
| SCHEMBL8547313 | 0.90 | EDNRB (0.53) | EDNRBEDNRAPOLBGAAMAPT | |
| SCHEMBL8547526 | 0.89 | EDNRB (0.59) | EDNRBEDNRAPOLB | |
| SCHEMBL8551092 | 0.89 | EDNRB (0.59) | EDNRBEDNRAPOLB | |
| SCHEMBL8548994 | 0.86 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8589486 | 0.84 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8551766 | 0.84 | EDNRB (0.43) | EDNRBEDNRAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |