Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.59 |
| ▸ | EDNRA | P25101 | 9/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547313 | 0.94 | EDNRB (0.53) | EDNRBEDNRAPPARGPOLB | |
| SCHEMBL8547982 | 0.93 | EDNRB (0.60) | EDNRBEDNRA | |
| SCHEMBL8551764 | 0.93 | EDNRB (0.53) | EDNRBEDNRAPOLB | |
| SCHEMBL8552694 | 0.91 | EDNRB (0.58) | EDNRBEDNRA | |
| SCHEMBL8551096 | 0.91 | EDNRB (0.50) | EDNRBEDNRAPPARGPOLBAGTR1 | |
| SCHEMBL8549171 | 0.89 | EDNRB (0.72) | EDNRBEDNRAPPARG | |
| SCHEMBL8550571 | 0.89 | EDNRB (0.49) | EDNRBEDNRAPOLB | |
| SCHEMBL8548406 | 0.87 | EDNRB (0.54) | EDNRBEDNRAPOLB | |
| SCHEMBL8548994 | 0.86 | EDNRB (0.53) | EDNRBEDNRA | |
| SCHEMBL8549367 | 0.85 | EDNRB (0.52) | EDNRBEDNRAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |