Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 16/20 | 0.72 |
| ▸ | EDNRA | P25101 | 15/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313368 | 0.87 | EDNRB (0.94) | EDNRBEDNRA | |
| SCHEMBL8547840 | 0.81 | EDNRB (0.68) | EDNRBEDNRA | |
| SCHEMBL8552129 | 0.81 | EDNRB (0.63) | EDNRBEDNRAMAPTLMNASMN1; SMN2 | |
| SCHEMBL8551270 | 0.80 | EDNRB (0.65) | EDNRBEDNRALMNAKDM4E | |
| SCHEMBL8550420 | 0.80 | EDNRB (0.61) | EDNRBEDNRAMAPTLMNASMN1; SMN2 | |
| SCHEMBL8552935 | 0.79 | EDNRB (0.60) | EDNRBEDNRAMAPTLMNASMN1; SMN2 | |
| SCHEMBL8594148 | 0.73 | EDNRB (0.79) | EDNRBEDNRA | |
| SCHEMBL8547246 | 0.73 | EDNRA (0.81) | EDNRBEDNRA | |
| SCHEMBL8547997 | 0.72 | EDNRB (0.54) | EDNRBEDNRAMAPTTSHRHSD17B10 | |
| SCHEMBL8594151 | 0.72 | EDNRB (0.63) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |