Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.55 |
| ▸ | EDNRA | P25101 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551990 | 0.92 | EDNRB (0.51) | EDNRBEDNRA | |
| SCHEMBL8553567 | 0.91 | EDNRB (0.67) | EDNRBEDNRA | |
| SCHEMBL8551085 | 0.91 | EDNRB (0.45) | EDNRBEDNRAPOLBTP53NTRK1 | |
| SCHEMBL8548124 | 0.89 | EDNRB (0.56) | EDNRBEDNRA | |
| SCHEMBL8549513 | 0.88 | EDNRB (0.57) | EDNRBEDNRAPOLBTP53KDM4E | |
| SCHEMBL8551372 | 0.87 | EDNRB (0.57) | EDNRBEDNRAPOLBTP53KDM4E | |
| SCHEMBL8550378 | 0.86 | EDNRB (0.51) | EDNRBEDNRATP53 | |
| SCHEMBL8551061 | 0.85 | EDNRB (0.57) | EDNRBEDNRAPOLBTP53KDM4E | |
| SCHEMBL8547943 | 0.85 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL8553569 | 0.83 | EDNRB (0.54) | EDNRBEDNRAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |