Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.54 |
| ▸ | EDNRA | P25101 | 4/20 | 0.42 |
| ▸ | BMP1 | P13497 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547944 | 0.93 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL8548125 | 0.93 | EDNRB (0.45) | EDNRBEDNRAPOLBKMT2A | |
| SCHEMBL8551085 | 0.91 | EDNRB (0.45) | EDNRBEDNRABMP1POLBMAPT | |
| SCHEMBL8548902 | 0.91 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8553567 | 0.90 | EDNRB (0.67) | EDNRBEDNRAPPARGKMT2A | |
| SCHEMBL8550380 | 0.89 | EDNRB (0.41) | EDNRBEDNRAKEAP1NFE2L2 | |
| SCHEMBL8551995 | 0.88 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL8591727 | 0.87 | EDNRB (0.56) | EDNRBEDNRAPOLBMAPTPPARG | |
| SCHEMBL8551968 | 0.87 | EDNRB (0.55) | EDNRBEDNRAPOLBMAPTPPARG | |
| SCHEMBL8546601 | 0.87 | EDNRB (0.51) | EDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |