Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR1B | P28222 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 7/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CPT1A | P50416 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31579432 | 0.85 | HTT (0.49) | HTTHTR1AHTR1BMEN1KMT2A | |
| SCHEMBL8549655 | 0.85 | HTT (0.66) | HTTHTR1AHTR1BMEN1KMT2A | |
| SCHEMBL24906138 | 0.83 | NR4A2 (0.66) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7448403 | 0.82 | HTR1D (0.57) | MEN1KMT2AALDH1A1MAPTHTR1D | |
| SCHEMBL31377509 | 0.80 | NR4A2 (0.54) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29989077 | 0.79 | NR4A2 (0.50) | HTR1AMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL12721389 | 0.76 | MAPT (0.71) | HTTHTR1AHTR1BMEN1KMT2A | |
| SCHEMBL5176370 | 0.75 | HPGD (0.46) | CYP2C19ALDH1A1LMNARAB9ANR4A2 | |
| SCHEMBL30622613 | 0.75 | KDM4E (0.55) | KMT2AALDH1A1KDM4EHTR2AMTNR1A | |
| SCHEMBL24243764 | 0.75 | KDM4E (0.55) | KMT2AALDH1A1KDM4EHTR2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593513-B1 | TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5571833-A | TREATMENT OF MIGRAINE, PORTAL HYPERTENSION | SMITHKLINE BEECHAM PLC (GB) | 1996-11-05 | — | — | US | disclosed |