SCHEMBL8551174

SCHEMBL8551174

O=c1[nH]c(=O)n(Cc2ccc(Oc3cccc(Oc4ccc(Cn5oc(=O)[nH]c5=O)cc4C(F)(F)F)c3)c(C(F)(F)F)c2)o1

nearest known ligand 0.42

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PLAT P00750 9/20 0.42
FFAR1 O14842 1/20 0.38
PTDSS1 P48651 1/20 0.35
EPAS1 Q99814 1/20 0.35
BRAF P15056 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8547072 0.85 DAO (0.41) PLATFFAR1
SCHEMBL8550355 0.83 PLAT (0.42) PLATFFAR1
SCHEMBL8953815 0.81 PLAT (0.53) PLATFFAR1
SCHEMBL8547134 0.80 PLAT (0.40) PLATFFAR1
SCHEMBL8544251 0.80 FFAR1 (0.48) PLATFFAR1
SCHEMBL8547757 0.73 DAO (0.50) PLATFFAR1
SCHEMBL12578800 0.73 PLAT (0.54) PLATFFAR1
SCHEMBL5721090 0.72 PLAT (0.58) PLAT
SCHEMBL5427495 0.72 PLAT (0.57) PLATFFAR1
SCHEMBL12579978 0.71 FFAR1 (0.60) PLATFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed