SCHEMBL8550355

SCHEMBL8550355

O=c1[nH]c(=O)n(Cc2ccc(Oc3cccc(Oc4ccc(Cn5oc(=O)[nH]c5=O)cc4Cl)c3)c(Cl)c2)o1

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PLAT P00750 9/20 0.42
FFAR1 O14842 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.36
DAO P14920 2/20 0.35
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
PTPN1 P18031 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8547072 0.86 DAO (0.41) PLATFFAR1DAOPTPN1
SCHEMBL8544251 0.85 FFAR1 (0.48) PLATFFAR1DAO
SCHEMBL8551174 0.83 PLAT (0.42) PLATFFAR1
SCHEMBL8546217 0.83 PLAT (0.45) PLATFFAR1DAO
SCHEMBL8545154 0.81 PLAT (0.46) PLATFFAR1DAO
SCHEMBL8547757 0.78 DAO (0.50) PLATFFAR1DAO
SCHEMBL8550234 0.78 PLAT (0.44) PLATFFAR1DAOPTPN1
SCHEMBL8953815 0.77 PLAT (0.53) PLATFFAR1PTPN1
SCHEMBL8546158 0.76 PLAT (0.48) PLATFFAR1
SCHEMBL8546551 0.76 FFAR1 (0.46) PLATFFAR1DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed