Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 9/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552680 | 0.90 | PDGFRA (0.54) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8556665 | 0.90 | PDGFRA (0.59) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8552480 | 0.88 | PDGFRA (0.67) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL31105478 | 0.84 | KDR (0.55) | PDGFRAKDRKIT | |
| SCHEMBL8554464 | 0.82 | PDGFRA (0.56) | PDGFRAKDRPDGFRBFGFR2 | |
| SCHEMBL8554120 | 0.82 | PDGFRA (0.58) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8554994 | 0.80 | PDGFRA (0.57) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8552659 | 0.80 | PDGFRA (0.67) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8551093 | 0.79 | AXL (0.56) | PDGFRAKDRPDGFRBFGFR2KIT | |
| SCHEMBL8555319 | 0.79 | PDGFRA (0.63) | PDGFRAKDRPDGFRBFGFR2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |